SimplyMEPIS is a commercial distribution very similar to Knoppix. It provides a turn-key Linux system from a LiveCD, and includes a number of non-free software packages: device drivers for nVidia video cards, Flash for animations embedded in many websites, RealPlayer, Sun's Java, and so on. The goal is to provide a 100 % working system out of the box. Mepis is internationalized and handles many languages.

This distribution was originally based on Debian; it went to Ubuntu for a while, then came back to Debian Stable, which allows its developers to focus on adding features without having to stabilize packages coming from Debian's Unstable distribution.